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Prasada Rao, M. M.
- Anti-Inflammatory Activity of Ethanolic Extract of Basella alba in Acute and Sub-Acute Model
Abstract Views :180 |
PDF Views:3
Authors
Naidu Narapusetty
1,
O. Sivaiah
1,
B. Balanasaraiah
1,
M. Haranadhbabu
1,
B. Prasad
1,
B. Hosanna Crown
1,
M. M. Prasada Rao
2
Affiliations
1 Department of Pharmacology, Bellamkonda Institute of Technology and Sciences, Podili, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, IN
1 Department of Pharmacology, Bellamkonda Institute of Technology and Sciences, Podili, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 2 (2017), Pagination: 88-93Abstract
The present study is carried out to investigate the anti-inflammatory potential of Ethanolic extract of Basella alba (BA). Anti-inflammatory activity was evaluated by using Egg Albumin, Turpentine Oil and Formaldehyde as phlogistic agents. The animals were treated with doses 250mg/kg and 500mg/kg of extract and Diclofenac Sodium at a dose of 10mg/kg is used as a standard drug. The BA showed a significant anti-inflammatory activity in a dose dependent manner in all the models when compared with the standard treatment. The extract (500mg/kg) exhibited maximum antiinflammatory activity i.e., 46.25%, 44.30%, 46.40% (P<0.001) like standard Diclofenac 47.02%, 46.50%, 48.57% in Egg albumin, Turpentine oil and Formaldehyde induced methods respectively. Based on the above results, we conclude that the BA has significant anti-inflammatory activity and might prove efficacious for further design and development of agents with significant biological activity.Keywords
Basella alba, Anti-Inflammatory Activity, Phlogistic Agents.- Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Amlodipine Besylate (AMB)
Abstract Views :244 |
PDF Views:7
Authors
V. Jhansipriya Marabathuni
1,
P. Dinesh
1,
R. Ravikumar
1,
P. Yamini
1,
P. Sai Kiran
1,
P. Hussain
1,
M. M. Prasada Rao
2
Affiliations
1 Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, IN
1 Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 2 (2017), Pagination: 97-104Abstract
The buccal region of the oral cavity is an attractive target for administration of the drug of choice. Sustained release formulations have been developed and are gaining in popularity and medical acceptance. To increase bioavailability and prevent first pass metabolism of drug, Amlodipine besylate was embedded in sustained released buccal patch over period of 6 hour. The objective of present work was to characterize the effect of chitosan with PVP K-30 on water soluble drug by preparing mucoadhesive buccal patch. Each formulated batch was subjected to various evaluation parameters. The swelling percentage was found to be function of solubility of drug and PVP K-30. The mucoadhesive strength, vapour transmission and in-vitro released of water soluble drug through water insoluble chitosan base matrix were found satisfactorily. The AMB shows some suitability with those polymers.Keywords
Buccal Patch, Sustained Drug Delivery, Bioadhesion, Mucoadhesive Buccal Delivery.- Synthesis, Characterization and Biological Evaluation of Benzothiazole Derivatives as Potential Antimicrobial and Analgesic Agents
Abstract Views :227 |
PDF Views:7
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole-523272, IN
1 Department of Pharmaceutical Chemistry, Hindu College of Pharmacy, Amaravathi Road, Guntur, IN
2 Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole-523272, IN